Peripheral CD19+CD24highCD38high B-regulatory cells in lung transplant recipients.
Identifieur interne : 000261 ( Main/Exploration ); précédent : 000260; suivant : 000262Peripheral CD19+CD24highCD38high B-regulatory cells in lung transplant recipients.
Auteurs : Davide Piloni [Italie] ; Monica Morosini [Italie] ; Sara Magni [Italie] ; Alice Balderacchi [Italie] ; Simona Inghilleri [Italie] ; Emanuela Cova [Italie] ; Tiberio Oggionni [Italie] ; Vanessa Frangipane [Italie] ; Laura Pandolfi [Italie] ; Luigia Scudeller [Italie] ; Federica Meloni [Italie]Source :
- Transplant immunology [ 1878-5492 ] ; 2019.
Descripteurs français
- KwdFr :
- Acide mycophénolique (usage thérapeutique), Adulte (MeSH), Adulte d'âge moyen (MeSH), Antigènes CD24 (métabolisme), Antigènes CD38 (métabolisme), Aspergillose pulmonaire (épidémiologie), Aspergillus fumigatus (physiologie), Circulation sanguine (MeSH), Femelle (MeSH), Humains (MeSH), Immunophénotypage (MeSH), Infections de l'appareil respiratoire (épidémiologie), Infections à staphylocoques (épidémiologie), Interleukine-10 (métabolisme), Italie (épidémiologie), Lymphocytes B régulateurs (immunologie), Lymphocytes T régulateurs (immunologie), Maladie chronique (MeSH), Mâle (MeSH), Néprilysine (métabolisme), Rejet du greffon (immunologie), Rejet du greffon (épidémiologie), Staphylococcus aureus (physiologie), Transplantation pulmonaire (MeSH), Études de cohortes (MeSH).
- MESH :
- immunologie : Lymphocytes B régulateurs, Lymphocytes T régulateurs, Rejet du greffon.
- métabolisme : Antigènes CD24, Antigènes CD38, Interleukine-10, Néprilysine.
- physiologie : Aspergillus fumigatus, Staphylococcus aureus.
- usage thérapeutique : Acide mycophénolique.
- épidémiologie : Aspergillose pulmonaire, Infections de l'appareil respiratoire, Infections à staphylocoques, Italie, Rejet du greffon.
- Adulte, Adulte d'âge moyen, Circulation sanguine, Femelle, Humains, Immunophénotypage, Maladie chronique, Mâle, Transplantation pulmonaire, Études de cohortes.
- Wicri :
- geographic : Italie.
English descriptors
- KwdEn :
- ADP-ribosyl Cyclase 1 (metabolism), Adult (MeSH), Aspergillus fumigatus (physiology), B-Lymphocytes, Regulatory (immunology), Blood Circulation (MeSH), CD24 Antigen (metabolism), Chronic Disease (MeSH), Cohort Studies (MeSH), Female (MeSH), Graft Rejection (epidemiology), Graft Rejection (immunology), Humans (MeSH), Immunophenotyping (MeSH), Interleukin-10 (metabolism), Italy (epidemiology), Lung Transplantation (MeSH), Male (MeSH), Middle Aged (MeSH), Mycophenolic Acid (therapeutic use), Neprilysin (metabolism), Pulmonary Aspergillosis (epidemiology), Respiratory Tract Infections (epidemiology), Staphylococcal Infections (epidemiology), Staphylococcus aureus (physiology), T-Lymphocytes, Regulatory (immunology).
- MESH :
- chemical , metabolism : ADP-ribosyl Cyclase 1, CD24 Antigen, Interleukin-10, Neprilysin.
- geographic , epidemiology : Italy.
- epidemiology : Graft Rejection, Pulmonary Aspergillosis, Respiratory Tract Infections, Staphylococcal Infections.
- immunology : B-Lymphocytes, Regulatory, Graft Rejection, T-Lymphocytes, Regulatory.
- physiology : Aspergillus fumigatus, Staphylococcus aureus.
- chemical , therapeutic use : Mycophenolic Acid.
- Adult, Blood Circulation, Chronic Disease, Cohort Studies, Female, Humans, Immunophenotyping, Lung Transplantation, Male, Middle Aged.
Abstract
BACKGROUND
The role of CD19+CD24
METHODS
From Jan 2009 to Dec 2014, 117 lung Tx recipients were submitted to an immunological follow up I-FU(median: 108.7 months (6.7-310.5)). Immunological follow up consisted of a complete blood peripheral immuno-phenotype, inclusive of CD19+CD24
RESULTS
Among all variables analyzed at multivariate analysis: chronic rejection (OR - 0.19, p = .039), use of Mycophenolate (OR - 0.38, p < .001) and the presence of a concomitant pulmonary infection of S. aureus (OR 0.66, p = .002) and A. fumigatus (OR 0.50, p = .009) were significantly associated to B-reg cell. No significant correlation between CD19+CD24
CONCLUSIONS
Our present data highlight, for the first time, that this cell subset might participate in long-term lung graft acceptance mechanisms.
DOI: 10.1016/j.trim.2019.101245
PubMed: 31526864
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Peripheral CD19+CD24<sup>high</sup>
CD38<sup>high</sup>
B-regulatory cells in lung transplant recipients.</title>
<author><name sortKey="Piloni, Davide" sort="Piloni, Davide" uniqKey="Piloni D" first="Davide" last="Piloni">Davide Piloni</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Section of Pneumology, University of Pavia, Pavia, Italy; Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy. Electronic address: davidepiloni@live.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Internal Medicine, Section of Pneumology, University of Pavia, Pavia, Italy; Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia</wicri:regionArea>
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<author><name sortKey="Morosini, Monica" sort="Morosini, Monica" uniqKey="Morosini M" first="Monica" last="Morosini">Monica Morosini</name>
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<author><name sortKey="Magni, Sara" sort="Magni, Sara" uniqKey="Magni S" first="Sara" last="Magni">Sara Magni</name>
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<author><name sortKey="Balderacchi, Alice" sort="Balderacchi, Alice" uniqKey="Balderacchi A" first="Alice" last="Balderacchi">Alice Balderacchi</name>
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<author><name sortKey="Inghilleri, Simona" sort="Inghilleri, Simona" uniqKey="Inghilleri S" first="Simona" last="Inghilleri">Simona Inghilleri</name>
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<author><name sortKey="Cova, Emanuela" sort="Cova, Emanuela" uniqKey="Cova E" first="Emanuela" last="Cova">Emanuela Cova</name>
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<author><name sortKey="Oggionni, Tiberio" sort="Oggionni, Tiberio" uniqKey="Oggionni T" first="Tiberio" last="Oggionni">Tiberio Oggionni</name>
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<author><name sortKey="Frangipane, Vanessa" sort="Frangipane, Vanessa" uniqKey="Frangipane V" first="Vanessa" last="Frangipane">Vanessa Frangipane</name>
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<author><name sortKey="Pandolfi, Laura" sort="Pandolfi, Laura" uniqKey="Pandolfi L" first="Laura" last="Pandolfi">Laura Pandolfi</name>
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<author><name sortKey="Scudeller, Luigia" sort="Scudeller, Luigia" uniqKey="Scudeller L" first="Luigia" last="Scudeller">Luigia Scudeller</name>
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<author><name sortKey="Meloni, Federica" sort="Meloni, Federica" uniqKey="Meloni F" first="Federica" last="Meloni">Federica Meloni</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Section of Pneumology, University of Pavia, Pavia, Italy; Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Internal Medicine, Section of Pneumology, University of Pavia, Pavia, Italy; Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia</wicri:regionArea>
<wicri:noRegion>Pavia</wicri:noRegion>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Peripheral CD19+CD24<sup>high</sup>
CD38<sup>high</sup>
B-regulatory cells in lung transplant recipients.</title>
<author><name sortKey="Piloni, Davide" sort="Piloni, Davide" uniqKey="Piloni D" first="Davide" last="Piloni">Davide Piloni</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Section of Pneumology, University of Pavia, Pavia, Italy; Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy. Electronic address: davidepiloni@live.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Internal Medicine, Section of Pneumology, University of Pavia, Pavia, Italy; Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia</wicri:regionArea>
<wicri:noRegion>Pavia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morosini, Monica" sort="Morosini, Monica" uniqKey="Morosini M" first="Monica" last="Morosini">Monica Morosini</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia</wicri:regionArea>
<wicri:noRegion>Pavia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Magni, Sara" sort="Magni, Sara" uniqKey="Magni S" first="Sara" last="Magni">Sara Magni</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia</wicri:regionArea>
<wicri:noRegion>Pavia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Balderacchi, Alice" sort="Balderacchi, Alice" uniqKey="Balderacchi A" first="Alice" last="Balderacchi">Alice Balderacchi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia</wicri:regionArea>
<wicri:noRegion>Pavia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Inghilleri, Simona" sort="Inghilleri, Simona" uniqKey="Inghilleri S" first="Simona" last="Inghilleri">Simona Inghilleri</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia</wicri:regionArea>
<wicri:noRegion>Pavia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cova, Emanuela" sort="Cova, Emanuela" uniqKey="Cova E" first="Emanuela" last="Cova">Emanuela Cova</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia</wicri:regionArea>
<wicri:noRegion>Pavia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oggionni, Tiberio" sort="Oggionni, Tiberio" uniqKey="Oggionni T" first="Tiberio" last="Oggionni">Tiberio Oggionni</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia</wicri:regionArea>
<wicri:noRegion>Pavia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Frangipane, Vanessa" sort="Frangipane, Vanessa" uniqKey="Frangipane V" first="Vanessa" last="Frangipane">Vanessa Frangipane</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia</wicri:regionArea>
<wicri:noRegion>Pavia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pandolfi, Laura" sort="Pandolfi, Laura" uniqKey="Pandolfi L" first="Laura" last="Pandolfi">Laura Pandolfi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia</wicri:regionArea>
<wicri:noRegion>Pavia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Scudeller, Luigia" sort="Scudeller, Luigia" uniqKey="Scudeller L" first="Luigia" last="Scudeller">Luigia Scudeller</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Epidemiology and Biometric Unit, Scientific Direction, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Clinical Epidemiology and Biometric Unit, Scientific Direction, IRCCS Policlinico San Matteo Foundation, Pavia</wicri:regionArea>
<wicri:noRegion>Pavia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meloni, Federica" sort="Meloni, Federica" uniqKey="Meloni F" first="Federica" last="Meloni">Federica Meloni</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Section of Pneumology, University of Pavia, Pavia, Italy; Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Internal Medicine, Section of Pneumology, University of Pavia, Pavia, Italy; Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia</wicri:regionArea>
<wicri:noRegion>Pavia</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Transplant immunology</title>
<idno type="eISSN">1878-5492</idno>
<imprint><date when="2019" type="published">2019</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ADP-ribosyl Cyclase 1 (metabolism)</term>
<term>Adult (MeSH)</term>
<term>Aspergillus fumigatus (physiology)</term>
<term>B-Lymphocytes, Regulatory (immunology)</term>
<term>Blood Circulation (MeSH)</term>
<term>CD24 Antigen (metabolism)</term>
<term>Chronic Disease (MeSH)</term>
<term>Cohort Studies (MeSH)</term>
<term>Female (MeSH)</term>
<term>Graft Rejection (epidemiology)</term>
<term>Graft Rejection (immunology)</term>
<term>Humans (MeSH)</term>
<term>Immunophenotyping (MeSH)</term>
<term>Interleukin-10 (metabolism)</term>
<term>Italy (epidemiology)</term>
<term>Lung Transplantation (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Mycophenolic Acid (therapeutic use)</term>
<term>Neprilysin (metabolism)</term>
<term>Pulmonary Aspergillosis (epidemiology)</term>
<term>Respiratory Tract Infections (epidemiology)</term>
<term>Staphylococcal Infections (epidemiology)</term>
<term>Staphylococcus aureus (physiology)</term>
<term>T-Lymphocytes, Regulatory (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acide mycophénolique (usage thérapeutique)</term>
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Antigènes CD24 (métabolisme)</term>
<term>Antigènes CD38 (métabolisme)</term>
<term>Aspergillose pulmonaire (épidémiologie)</term>
<term>Aspergillus fumigatus (physiologie)</term>
<term>Circulation sanguine (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Immunophénotypage (MeSH)</term>
<term>Infections de l'appareil respiratoire (épidémiologie)</term>
<term>Infections à staphylocoques (épidémiologie)</term>
<term>Interleukine-10 (métabolisme)</term>
<term>Italie (épidémiologie)</term>
<term>Lymphocytes B régulateurs (immunologie)</term>
<term>Lymphocytes T régulateurs (immunologie)</term>
<term>Maladie chronique (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Néprilysine (métabolisme)</term>
<term>Rejet du greffon (immunologie)</term>
<term>Rejet du greffon (épidémiologie)</term>
<term>Staphylococcus aureus (physiologie)</term>
<term>Transplantation pulmonaire (MeSH)</term>
<term>Études de cohortes (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>ADP-ribosyl Cyclase 1</term>
<term>CD24 Antigen</term>
<term>Interleukin-10</term>
<term>Neprilysin</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Italy</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Graft Rejection</term>
<term>Pulmonary Aspergillosis</term>
<term>Respiratory Tract Infections</term>
<term>Staphylococcal Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes B régulateurs</term>
<term>Lymphocytes T régulateurs</term>
<term>Rejet du greffon</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>B-Lymphocytes, Regulatory</term>
<term>Graft Rejection</term>
<term>T-Lymphocytes, Regulatory</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes CD24</term>
<term>Antigènes CD38</term>
<term>Interleukine-10</term>
<term>Néprilysine</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Aspergillus fumigatus</term>
<term>Staphylococcus aureus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aspergillus fumigatus</term>
<term>Staphylococcus aureus</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Mycophenolic Acid</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Acide mycophénolique</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Aspergillose pulmonaire</term>
<term>Infections de l'appareil respiratoire</term>
<term>Infections à staphylocoques</term>
<term>Italie</term>
<term>Rejet du greffon</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Blood Circulation</term>
<term>Chronic Disease</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Immunophenotyping</term>
<term>Lung Transplantation</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Circulation sanguine</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunophénotypage</term>
<term>Maladie chronique</term>
<term>Mâle</term>
<term>Transplantation pulmonaire</term>
<term>Études de cohortes</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Italie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>The role of CD19+CD24</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>From Jan 2009 to Dec 2014, 117 lung Tx recipients were submitted to an immunological follow up I-FU(median: 108.7 months (6.7-310.5)). Immunological follow up consisted of a complete blood peripheral immuno-phenotype, inclusive of CD19+CD24</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Among all variables analyzed at multivariate analysis: chronic rejection (OR - 0.19, p = .039), use of Mycophenolate (OR - 0.38, p < .001) and the presence of a concomitant pulmonary infection of S. aureus (OR 0.66, p = .002) and A. fumigatus (OR 0.50, p = .009) were significantly associated to B-reg cell. No significant correlation between CD19+CD24</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Our present data highlight, for the first time, that this cell subset might participate in long-term lung graft acceptance mechanisms.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31526864</PMID>
<DateCompleted><Year>2020</Year>
<Month>05</Month>
<Day>08</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>05</Month>
<Day>08</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-5492</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>57</Volume>
<PubDate><Year>2019</Year>
<Month>12</Month>
</PubDate>
</JournalIssue>
<Title>Transplant immunology</Title>
<ISOAbbreviation>Transpl Immunol</ISOAbbreviation>
</Journal>
<ArticleTitle>Peripheral CD19+CD24<sup>high</sup>
CD38<sup>high</sup>
B-regulatory cells in lung transplant recipients.</ArticleTitle>
<Pagination><MedlinePgn>101245</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0966-3274(19)30070-X</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.trim.2019.101245</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">The role of CD19+CD24<sup>high</sup>
CD38<sup>high</sup>
B-regulatory cells in solid-organ Transplant (Tx) in acceptance are still scarce. In previous studies on kidney transplant recipients may suggest a protective role of this cell subtype in graft tolerance and the existence of a cross talk between B-and T-regulatory clones. In lung transplantation, the role of B-regulatory cells has never been investigated. In a murine tracheal transplantation model, this subset seems able to prevent tracheal obliteration when in combination with rapamycin. Aim of this study is to analyze peripheral CD19+CD24<sup>high</sup>
CD38<sup>high</sup>
B-reg cells counts in a cohort of lung recipients, their association with several clinical and pharmacological variables and their possible association with T regulatory cell.</AbstractText>
<AbstractText Label="METHODS">From Jan 2009 to Dec 2014, 117 lung Tx recipients were submitted to an immunological follow up I-FU(median: 108.7 months (6.7-310.5)). Immunological follow up consisted of a complete blood peripheral immuno-phenotype, inclusive of CD19+CD24<sup>high</sup>
CD38<sup>high</sup>
B-cells (globally 1106 determinations). We tested the association between B-reg and relevant variables by linear or regression models for repeated measures, adjusting for time from Tx.</AbstractText>
<AbstractText Label="RESULTS">Among all variables analyzed at multivariate analysis: chronic rejection (OR - 0.19, p = .039), use of Mycophenolate (OR - 0.38, p < .001) and the presence of a concomitant pulmonary infection of S. aureus (OR 0.66, p = .002) and A. fumigatus (OR 0.50, p = .009) were significantly associated to B-reg cell. No significant correlation between CD19+CD24<sup>high</sup>
CD38<sup>high</sup>
B-reg cells and T-reg cells counts was found in our cohort.</AbstractText>
<AbstractText Label="CONCLUSIONS">Our present data highlight, for the first time, that this cell subset might participate in long-term lung graft acceptance mechanisms.</AbstractText>
<CopyrightInformation>Copyright © 2019 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Piloni</LastName>
<ForeName>Davide</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Section of Pneumology, University of Pavia, Pavia, Italy; Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy. Electronic address: davidepiloni@live.it.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Morosini</LastName>
<ForeName>Monica</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Magni</LastName>
<ForeName>Sara</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Balderacchi</LastName>
<ForeName>Alice</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Inghilleri</LastName>
<ForeName>Simona</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cova</LastName>
<ForeName>Emanuela</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Oggionni</LastName>
<ForeName>Tiberio</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Frangipane</LastName>
<ForeName>Vanessa</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pandolfi</LastName>
<ForeName>Laura</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Scudeller</LastName>
<ForeName>Luigia</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Clinical Epidemiology and Biometric Unit, Scientific Direction, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Meloni</LastName>
<ForeName>Federica</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Section of Pneumology, University of Pavia, Pavia, Italy; Department of Medical Sciences and Infective Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>09</Month>
<Day>14</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Transpl Immunol</MedlineTA>
<NlmUniqueID>9309923</NlmUniqueID>
<ISSNLinking>0966-3274</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D051927">CD24 Antigen</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>130068-27-8</RegistryNumber>
<NameOfSubstance UI="D016753">Interleukin-10</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.2.2.6</RegistryNumber>
<NameOfSubstance UI="D051997">ADP-ribosyl Cyclase 1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.24.11</RegistryNumber>
<NameOfSubstance UI="D015260">Neprilysin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>HU9DX48N0T</RegistryNumber>
<NameOfSubstance UI="D009173">Mycophenolic Acid</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D051997" MajorTopicYN="N">ADP-ribosyl Cyclase 1</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001232" MajorTopicYN="N">Aspergillus fumigatus</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060151" MajorTopicYN="N">B-Lymphocytes, Regulatory</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001775" MajorTopicYN="N">Blood Circulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051927" MajorTopicYN="N">CD24 Antigen</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002908" MajorTopicYN="N">Chronic Disease</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006084" MajorTopicYN="N">Graft Rejection</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016130" MajorTopicYN="N">Immunophenotyping</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016753" MajorTopicYN="N">Interleukin-10</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007558" MajorTopicYN="N" Type="Geographic">Italy</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016040" MajorTopicYN="Y">Lung Transplantation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009173" MajorTopicYN="N">Mycophenolic Acid</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015260" MajorTopicYN="N">Neprilysin</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055732" MajorTopicYN="N">Pulmonary Aspergillosis</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012141" MajorTopicYN="N">Respiratory Tract Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013203" MajorTopicYN="N">Staphylococcal Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013211" MajorTopicYN="N">Staphylococcus aureus</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050378" MajorTopicYN="N">T-Lymphocytes, Regulatory</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">B-regulatory cell</Keyword>
<Keyword MajorTopicYN="Y">Chronic lung allograft dysfunction</Keyword>
<Keyword MajorTopicYN="Y">Immunology</Keyword>
<Keyword MajorTopicYN="Y">Long-term follow-up</Keyword>
<Keyword MajorTopicYN="Y">Lung transplantation</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year>
<Month>05</Month>
<Day>29</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2019</Year>
<Month>09</Month>
<Day>07</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2019</Year>
<Month>09</Month>
<Day>13</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>9</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>5</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>9</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">31526864</ArticleId>
<ArticleId IdType="pii">S0966-3274(19)30070-X</ArticleId>
<ArticleId IdType="doi">10.1016/j.trim.2019.101245</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Italie</li>
</country>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Piloni, Davide" sort="Piloni, Davide" uniqKey="Piloni D" first="Davide" last="Piloni">Davide Piloni</name>
</noRegion>
<name sortKey="Balderacchi, Alice" sort="Balderacchi, Alice" uniqKey="Balderacchi A" first="Alice" last="Balderacchi">Alice Balderacchi</name>
<name sortKey="Cova, Emanuela" sort="Cova, Emanuela" uniqKey="Cova E" first="Emanuela" last="Cova">Emanuela Cova</name>
<name sortKey="Frangipane, Vanessa" sort="Frangipane, Vanessa" uniqKey="Frangipane V" first="Vanessa" last="Frangipane">Vanessa Frangipane</name>
<name sortKey="Inghilleri, Simona" sort="Inghilleri, Simona" uniqKey="Inghilleri S" first="Simona" last="Inghilleri">Simona Inghilleri</name>
<name sortKey="Magni, Sara" sort="Magni, Sara" uniqKey="Magni S" first="Sara" last="Magni">Sara Magni</name>
<name sortKey="Meloni, Federica" sort="Meloni, Federica" uniqKey="Meloni F" first="Federica" last="Meloni">Federica Meloni</name>
<name sortKey="Morosini, Monica" sort="Morosini, Monica" uniqKey="Morosini M" first="Monica" last="Morosini">Monica Morosini</name>
<name sortKey="Oggionni, Tiberio" sort="Oggionni, Tiberio" uniqKey="Oggionni T" first="Tiberio" last="Oggionni">Tiberio Oggionni</name>
<name sortKey="Pandolfi, Laura" sort="Pandolfi, Laura" uniqKey="Pandolfi L" first="Laura" last="Pandolfi">Laura Pandolfi</name>
<name sortKey="Scudeller, Luigia" sort="Scudeller, Luigia" uniqKey="Scudeller L" first="Luigia" last="Scudeller">Luigia Scudeller</name>
</country>
</tree>
</affiliations>
</record>
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